abstract：:Epigallocatechin gallate(EGCG) is a monomer separated from tea catechins, as an well-known antioxidant, which helps fight wrinkles and rejuvenate skin cells. In this study, we investigated the anti-aging effect of EGCG, and to clarify underlying mechanism of skin aging in a d-galactose-induced aging mouse model. Forty...

journal_title：Mechanisms of ageing and development

authors： Chen J,Li Y,Zhu Q,Li T,Lu H,Wei N,Huang Y,Shi R,Ma X,Wang X,Sheng J

更新日期：2017-06-01 00:00:00

abstract：:Chronic health conditions are commonplace in older populations. The process of aging impacts many of the world's top health concerns. With the average life expectancy continuing to climb, understanding patterns of morbidity in aging populations has become progressively more important. Cancer is an age-related disease,...

journal_title：Mechanisms of ageing and development

authors： Nolen SC,Evans MA,Fischer A,Corrada MM,Kawas CH,Bota DA

更新日期：2017-06-01 00:00:00

abstract：OBJECTIVES:To investigate whether systemic inflammation in acutely admitted older medical patients (age >65 years) is associated with physical performance and organ dysfunction. Organ dysfunction´s association with physical performance, and whether these associations are mediated by systemic inflammation, was also inve...

journal_title：Mechanisms of ageing and development

authors： Klausen HH,Bodilsen AC,Petersen J,Bandholm T,Haupt T,Sivertsen DM,Andersen O

更新日期：2017-06-01 00:00:00

abstract：:Menopause is characterized by the depletion of estrogen that has been proposed to cause oxidative stress. Circadian rhythm is an internal biological clock that controls physiological processes. It was analyzed the gene expression in peripheral blood mononuclear cells and the lipids and glucose levels in plasma of a su...

journal_title：Mechanisms of ageing and development

authors： Rangel-Zuñiga OA,Cruz-Teno C,Haro C,Quintana-Navarro GM,Camara-Martos F,Perez-Martinez P,Garcia-Rios A,Garaulet M,Tena-Sempere M,Lopez-Miranda J,Perez-Jimenez F,Camargo A

更新日期：2017-06-01 00:00:00

abstract：:The present work explores the application of information theoretical measures, such as entropy and normalized mutual information, for research of biomarkers of aging. The use of information theory affords unique methodological advantages for the study of aging processes, as it allows evaluating non-linear relations be...

journal_title：Mechanisms of ageing and development

authors： Blokh D,Stambler I

更新日期：2017-04-01 00:00:00

abstract：:Periodontal diseases are partly attributable to periodontopathic bacteria found in the host, whereas, butyric acid (BA) is a common secondary metabolite produced by periodontopathic bacterial pathogens. BA has been linked to oxidative stress induction while oxidative stress has long been associated with the ageing pro...

journal_title：Mechanisms of ageing and development

authors： Cueno ME,Seki K,Ochiai K,Imai K

更新日期：2017-03-01 00:00:00

abstract：:Age-associated changes in lung structure and function are some of the most important predictors of overall health, cognitive activities and longevity. Common to all aging cells is an increase in oxidatively modified DNA bases, primarily 8-oxo-7,8-dihydroguanine (8-oxoG). It is repaired via DNA base excision repair pat...

journal_title：Mechanisms of ageing and development

authors： German P,Saenz D,Szaniszlo P,Aguilera-Aguirre L,Pan L,Hegde ML,Bacsi A,Hajas G,Radak Z,Ba X,Mitra S,Papaconstantinou J,Boldogh I

更新日期：2017-01-01 00:00:00

abstract：:Alpha-synuclein (syn) is the main component of proteinaceous inclusions known as Lewy bodies (LBs), which are implicated in the pathogenesis of the neurodegenerative diseases known as synucleinopathies, like Parkinson's disease (PD). Aging is a major risk factor for PD and thus, interventions that delay aging will hav...

journal_title：Mechanisms of ageing and development

authors： Guedes A,Ludovico P,Sampaio-Marques B

更新日期：2017-01-01 00:00:00

abstract：:This article has been retracted: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our-business/policies/article-withdrawal). This article has been retracted at the request of Marie-Ange Teste, Isabelle Léger-Silvestre, Jean M François and Jean-Luc Parrou. Marjorie Petitjean could not b...

journal_title：Mechanisms of ageing and development

authors： Petitjean M,Teste MA,Léger-Silvestre I,François JM,Parrou JL

更新日期：2017-01-01 00:00:00

abstract：:Ageing is a complex multifactorial process that results in many changes in physiological changes processes that ultimately increase susceptibility to a wide range of diseases. As such an ageing population is resulting in a pressing need for more and improved treatments across an assortment of diseases. Such treatments...

journal_title：Mechanisms of ageing and development

authors： Drechsler S,Lynch MA,Novella S,González-Navarro H,Hecimovic S,Barini E,Tucci V,Castro RE,Vandenbroucke RE,Osuchowski M,Potter PK

更新日期：2016-12-01 00:00:00

abstract：:Ageing is characterized by a decline in all systemic functions. A greater susceptibility to apoptosis and senescence may contribute to proliferative and functional impairment of endothelial progenitor cells. They play an important role in neo-angiogenesis and endothelial repair. Vascular ageing is associated with chan...

journal_title：Mechanisms of ageing and development

authors： Accardi G,Aiello A,Gambino CM,Virruso C,Caruso C,Candore G

更新日期：2016-10-01 00:00:00

abstract：:Preclinical and clinical studies suggest that specific subsets of cells isolated from the peripheral blood, play an essential role in the imbalance of damage and repair during age-associated diseases, such as metabolic syndrome, diabetes, atherosclerosis, neurodegenerative diseases, osteoporosis and cancer. Endogenous...

journal_title：Mechanisms of ageing and development

authors： Madonna R,Novo G,Balistreri CR

更新日期：2016-10-01 00:00:00

abstract：:Human cytomegalovirus (HCMV) establishes a highly prevalent life-long latent infection. Though generally subclinical, HCMV infection may have severe consequences during fetal development and in immunocompromised individuals. Based on epidemiological studies HCMV(+) serology has been associated with the development of ...

journal_title：Mechanisms of ageing and development

authors： López-Botet M,Muntasell A,Martínez-Rodríguez JE,López-Montañés M,Costa-García M,Pupuleku A

更新日期：2016-09-01 00:00:00

abstract：:Changes in the T cell pool caused by CMV infection have been proposed to contribute to immunosenescence, but it has been postulated that CMV can also have some beneficial effects in young individuals improving the immune response to other pathogens. T cells expressing CD56 (NKT-like cells) are cytotoxic effector cells...

journal_title：Mechanisms of ageing and development

authors： Hassouneh F,Campos C,López-Sejas N,Alonso C,Tarazona R,Solana R,Pera A

更新日期：2016-09-01 00:00:00

abstract：:In this study, we proposed a hypothesis that chromatin of mouse hepatocytes exhibits age-related reduction of fractal dimension. This hypothesis was based on previously published works demonstrating that complexity of biological systems such as tissues, decreases during the process of physiological aging. Liver tissue...

journal_title：Mechanisms of ageing and development

authors： Pantic I,Petrovic D,Paunovic J,Vucevic D,Radosavljevic T,Pantic S

更新日期：2016-07-01 00:00:00

abstract：:The progression of many neurodegenerative diseases is assumed to be caused by misfolding of specific characteristic diseases related proteins, resulting in aggregation and fibril formation of these proteins. Protein misfolding associated age related diseases, although different in disease manifestations, share strikin...

journal_title：Mechanisms of ageing and development

authors： Eftekharzadeh B,Hyman BT,Wegmann S

更新日期：2016-06-01 00:00:00

abstract：:Epigenetic disruption has been implicated in many diseases of aging, and age-associated DNA methylation changes at specific genomic loci in humans are strongly correlated with chronological age. The aim of this study was to explore the specificity of selected age-associated differentially methylated positions (aDMPs) ...

journal_title：Mechanisms of ageing and development

authors： Spiers H,Hannon E,Wells S,Williams B,Fernandes C,Mill J

更新日期：2016-03-01 00:00:00

abstract：:MARK-AGE aims at the identification of biomarkers of human aging capable of discriminating between the chronological age and the effective functional status of the organism. To achieve this, given the structure of the collected data, a proper statistical analysis has to be performed, as the structure of the data are n...

journal_title：Mechanisms of ageing and development

authors： Giampieri E,Remondini D,Bacalini MG,Garagnani P,Pirazzini C,Yani SL,Giuliani C,Menichetti G,Zironi I,Sala C,Capri M,Franceschi C,Bürkle A,Castellani G

更新日期：2015-11-01 00:00:00

abstract：:Population studies have demonstrated that telomere length (TL) displays great diversity among different populations. Previously described controversial findings associated longevity with specific mitochondrial DNA haplogroups (hgs) (e.g., J and U). These observations may be influenced by population diversity, geograph...

journal_title：Mechanisms of ageing and development

authors： Zole E,Elferts D,Kimsis J,Krumina A,Narels K,Pole I,Ranka R,Pliss L

更新日期：2015-01-01 00:00:00

abstract：:We present evidence of feed-forward loop relationships and positive association between physical activity and performance levels, which are components of frailty, using measures from 431 high functioning women initially aged 70-79 years followed over 7 visits. Physical activity levels were assessed using a questionnai...

journal_title：Mechanisms of ageing and development

authors： RoyChoudhury A,Dam TT,Varadhan R,Xue QL,Fried LP

更新日期：2014-11-01 00:00:00

abstract：:Iron deficiency anaemia is prevalent in older age, particularly after the age of 80. Serum ferritin concentrations also decline, although there is no evidence to suggest that changes in iron stores are an inevitable consequence of ageing. Chronic inflammation is a common condition in older people, making the measureme...

journal_title：Mechanisms of ageing and development

authors： Fairweather-Tait SJ,Wawer AA,Gillings R,Jennings A,Myint PK

更新日期：2014-03-01 00:00:00

abstract：BACKGROUND:The proportion of European elderly is expected to increase to 30% in 2060. Combining dietary components may modulate many processes involved in ageing. So, it is likely that a healthful diet approach might have greater favourable impact on age-related decline than individual dietary components. This paper de...

journal_title：Mechanisms of ageing and development

authors： Berendsen A,Santoro A,Pini E,Cevenini E,Ostan R,Pietruszka B,Rolf K,Cano N,Caille A,Lyon-Belgy N,Fairweather-Tait S,Feskens E,Franceschi C,de Groot CP

更新日期：2013-11-01 00:00:00

abstract：:The health status of the oldest old, the fastest increasing population segment worldwide, progressively becomes more heterogeneous, and this peculiarity represents a major obstacle to their classification. We compared the effectiveness of four previously proposed criteria (Franceschi et al., 2000; Evert et al., 2003; ...

journal_title：Mechanisms of ageing and development

authors： Cevenini E,Cotichini R,Stazi MA,Toccaceli V,Scurti M,Mari V,Berardelli M,Passarino G,Jeune B,Franceschi C,GEHA Project Consortium.

更新日期：2013-11-01 00:00:00

abstract：:Mycobacteria are an important group of pathogenic bacteria. We generated a series of DNA repair deficient strains of Mycobacterium smegmatis, a model organism, to understand the importance of various DNA repair proteins (UvrB, Ung, UdgB, MutY and Fpg) in survival of the pathogenic strains. Here, we compared tolerance ...

journal_title：Mechanisms of ageing and development

authors： Rex K,Kurthkoti K,Varshney U

更新日期：2013-10-01 00:00:00

abstract：:The cerebellum is exquisitely sensitive to deficiencies in the cellular response to specific DNA lesions. Genetic disorders caused by such deficiencies involve relentless, progressive cerebellar atrophy with striking loss of Purkinje and granule neurons. The reason for the extreme sensitivity of these cells to defecti...

journal_title：Mechanisms of ageing and development

authors： Tzur-Gilat A,Ziv Y,Mittelman L,Barzilai A,Shiloh Y

更新日期：2013-10-01 00:00:00

abstract：:It has been approximately 25 years since Dr. Rosenberg first brought attention to sarcopenia. To date, this aging-associated condition is recognized as a chronic loss of muscle mass and is usually accompanied by dynapenia. Despite its poly-etiological factors, sarcopenia has a strong neurogenic component underlying th...

journal_title：Mechanisms of ageing and development

authors： Kwan P

更新日期：2013-09-01 00:00:00

abstract：:Certain anatomic and functional parameters of the eye change with increasing chronological age. They may, therefore, serve as potential biomarkers of ageing. We investigated associations between four such ocular parameters (lens density, retinal vessel calibre, corneal endothelial cells and retinal nerve fibre layer t...

journal_title：Mechanisms of ageing and development

authors： Pathai S,Gilbert CE,Lawn SD,Weiss HA,Peto T,Cook C,Wong TY,Shiels PG

更新日期：2013-07-01 00:00:00

abstract：AIMS:To identify the geometrical alterations in the age-remodeled rat coronary artery network and to develop a useful technique to analyze network properties in the rat heart. METHODS AND RESULTS:We analyzed the networks of the left anterior descendent coronary arteries on in situ perfused hearts of young (3 months) a...

journal_title：Mechanisms of ageing and development

authors： Wappler EA,Antal P,Várbíró S,Székács B,Simon A,Nagy Z,Monos E,Nádasy GL

更新日期：2013-07-01 00:00:00

abstract：:Aging is a biological process associated with impairment of mitochondrial bioenergetic function, increased oxidative stress, attenuated ability to respond to stresses and increased risk in contracting age-associated diseases. When mitochondria are subjected to oxidative stress, accompanied by calcium overload and ATP ...

journal_title：Mechanisms of ageing and development

authors： Paradies G,Paradies V,Ruggiero FM,Petrosillo G

更新日期：2013-01-01 00:00:00

abstract：:Replicative senescence in human diploid fibroblasts is characterised by an exhaustion of proliferative potential and permanent cell cycle arrest. During senescence, telomere shortening-generated DNA damage activates p53 pathway that upregulates cell cycle inhibitors, such as p21. Human p400 ATPase is a chromatin remod...

journal_title：Mechanisms of ageing and development

authors： Lee K,Lau ZZ,Meredith C,Park JH

更新日期：2012-11-01 00:00:00

abstract：:The ascidian Ciona intestinalis has a short life span and powerful regeneration capacities. The regeneration of the oral siphon (OS) involves wound healing, blastema formation, cell proliferation, and replacement of 8 oral pigment organs (OPO), the latter via differentiation and migration of stem/precursor cells from ...

journal_title：Mechanisms of ageing and development

authors： Jeffery WR

更新日期：2012-09-01 00:00:00

abstract：:Senescence is thought to play an important role in the progressive age-related decline in tissue integrity and concomitant diseases, but not much is known about the complex interplay between upstream regulators and downstream effectors. We profiled whole genome gene expression of non-stressed and rotenone-stressed hum...

journal_title：Mechanisms of ageing and development

authors： Dekker P,Gunn D,McBryan T,Dirks RW,van Heemst D,Lim FL,Jochemsen AG,Verlaan-de Vries M,Nagel J,Adams PD,Tanke HJ,Westendorp RG,Maier AB

更新日期：2012-07-01 00:00:00

abstract：INTRODUCTION:Our objective was to study the impact of an identical additional stress on male and female mortality with a quasi-experimental study design, using natural variations in summer mortality, including the massive heat wave that struck Europe in 2003. MATERIAL AND METHODS:The summer daily mortality rates of th...

journal_title：Mechanisms of ageing and development

authors： Robine JM,Michel JP,Herrmann FR

更新日期：2012-06-01 00:00:00

abstract：:The incidence of chronic diseases such as cardiovascular diseases is lower in Mediterranean Southern Europe than Northern Europe. This may be due to a lower level of oxidative stress and a higher antioxidant status in people living around the Mediterranean Sea. Oxidative stress may influence the rate of shortening of ...

journal_title：Mechanisms of ageing and development

authors： de Vos-Houben JM,Ottenheim NR,Kafatos A,Buijsse B,Hageman GJ,Kromhout D,Giltay EJ

更新日期：2012-06-01 00:00:00

abstract：:The mTOR deregulation has a role in chronic kidney disease including diabetic nephropathy. SIRT1 is an important participant in renal cytoprotective responses to aging and stress. However, whether both mTOR and SIRT1 are involved in high glucose-inducing mesangial cells (MCs) senescence still remains to be explored. H...

journal_title：Mechanisms of ageing and development

authors： Zhang S,Cai G,Fu B,Feng Z,Ding R,Bai X,Liu W,Zhuo L,Sun L,Liu F,Chen X

更新日期：2012-06-01 00:00:00

abstract：:Adult Wistar NIN (WNIN) rats (6 months old) of both sexes were orally fed Amalakirasayana at a dose of 4.5 g per kg body weight, five days in a week. The Amalakirasayana was prepared by Arya Vaidya Sala, Kottakkal, Kerala, India, which is considered as gold standard. After 3, 9 and 15 months of such therapeutic regime...

journal_title：Mechanisms of ageing and development

authors： Swain U,Sindhu KK,Boda U,Pothani S,Giridharan NV,Raghunath M,Rao KS

更新日期：2012-04-01 00:00:00

abstract：:Detailed structural, mutational, and biochemical analyses of human FEN1/DNA complexes have revealed the mechanism for recognition of 5' flaps formed during lagging strand replication and DNA repair. FEN1 processes 5' flaps through a previously unknown, but structurally elegant double-stranded (ds) recognition/single s...

journal_title：Mechanisms of ageing and development

authors： Tsutakawa SE,Tainer JA

更新日期：2012-04-01 00:00:00

abstract：:The risk for developing colorectal cancer increases exponentially with age. We demonstrate that spontaneous loss of folate in the colon results in DNA damage accumulation and aberrant DNA damage responses that may contribute to the increased genomic instability and cancer risk in colon. We find greater than 2-fold cha...

journal_title：Mechanisms of ageing and development

authors： Simon KW,Ma H,Dombkowski AA,Cabelof DC

更新日期：2012-02-01 00:00:00

abstract：:Age-related loss of hearing and vision are two very common disabling conditions, but the underlying mechanisms are still poorly understood. Damage by reactive oxygen species and other reactive cellular metabolites, which in turn may damage macromolecules such as DNA, has been implicated in both processes. To investiga...

journal_title：Mechanisms of ageing and development

authors： Spoor M,Nagtegaal AP,Ridwan Y,Borgesius NZ,van Alphen B,van der Pluijm I,Hoeijmakers JH,Frens MA,Borst JG

更新日期：2012-02-01 00:00:00

abstract：:Influenza is a public health concern, especially for the elderly. While influenza vaccination is efficacious in the young, it offers only limited protection in the elderly. Thus, it becomes imperative to understand age-related changes in the primary response to influenza infection. This study identified potential age-...

journal_title：Mechanisms of ageing and development

authors： Beli E,Clinthorne JF,Duriancik DM,Hwang I,Kim S,Gardner EM

更新日期：2011-10-01 00:00:00